熊本大学大学院生命科学研究部 (保健学系) 構造機能解析学分野 大林研究室

業績 (2014年以降)

Ⅰ. 英文原著論文

  1. Yamashita T, Ueda M, Misumi Y, Masuda T, Nomura T, Tasaki M, Takamatsu K, Sasada K, Obayashi K, Matsui H, Ando Y.
    Genetic and clinical characteristics of hereditary transthyretin amyloidosis in endemic and non-endemic areas: experience from a single-referral center in Japan.
    J Neurol 265: 134-140, 2018.
  2. Tasaki M, Ueda M, Obayashi K, Kinoshita Y, Matsumoto S, Mizukami M, Masuda T, Misumi Y, Yamashita T, Ando Y.
    Identification of amyloid precursor protein from autopsy and biopsy specimens using LMD-LC-MS/MS: the experience at Kumamoto University.
    Amyloid 24: 167-168, 2017.
  3. Watanabe T, Obayashi K, Misumi Y, Tasaki M, Shinriki S, Ando T, Akagami T, Ueda M, Yamashita T, Hirotani S, Ando Y.
    Hereditary transthyretin amyloidosis associated with a transthyretin variant Thr59Arg.
    Amyloid 24: 119, 2017.
  4. Misumi Y, Oshima T, Ueda M, Yamashita T, Tasaki M, Masuda T, Obayashi K, Ando Y.
    Occurrence factors and clinical picture of iatrogenic transthyretin amyloidosis after domino liver transplantation.
    Amyloid 24: 123-124, 2017.
  5. Tsuda Y, Misumi Y, Ueda M, Tasaki M, Huang G, Masuda T, Suenaga G, Kinoshita Y, Obayashi K, Yamashita T, Ando Y.
    Iatrogenic systemic transthyretin amyloid deposits in a case with domino liver transplantation: an autopsy case study.
    Amyloid 24: 125, 2017.
  6. Yamashita T, Ueda M, Tasaki M, Masuda T, Misumi Y, Takamatsu K, Obayashi K, Ando Y.
    Establishment of a diagnostic center for amyloidosis in Japan by Kumamoto University.
    Amyloid 24: 169-170, 2017.
  7. Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y.
    Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.
    Neurology 88: 2192-2197, 2017.
  8. Obayashi K, Ueda M, Yamashita T, Tasaki M, Izaki A, Yanagisawa Y, Masuda T, Misumi Y, Ando Y.
    Long-term effects of liver transplantation on small-fiber dysfunction in Japanese transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP) ATTR V30M.
    Amyloid 24: 99, 2017.
  9. Yanagisawa Y, Obayashi K, Tasaki M, Izaki A, Masuda T, Misumi Y, Ueda M, Yamashita T, Ando Y.
    Clinicopathological characteristics of a patient with ureteral amyloidosis.
    Amyloid 24: 101, 2017.
  10. Izaki A, Obayashi K, Suenaga G, Ueda M, Yamashita T, Tasaki M, Yanagisawa Y, Masuda T, Misumi Y, Ando Y.
    In vitro and in vivo assessment of novel derivatives for detecting various amyloid deposits.
    Amyloid 24: 99, 2017.
  11. Huang G, Ueda M, Tasaki M, Yamashita T, Misumi Y, Masuda T, Suenaga G, Inoue Y, Kinoshita Y, Matsumoto S, Mizukami M, Tsuda Y, Nomura T, Obayashi K, Ando Y.
    Clinicopathological and biochemical findings of thyroid amyloid in hereditary transthyretin amyloidosis with and without liver transplantation.
    Amyloid 13: 1-6, 2017.
  12. Yamashita T, Ueda M, Saga N, Nanto K, Tasaki M, Masuda T, Misumi Y, Oda S, Fujimoto A, Amano T, Takamatsu K, Yamashita S, Obayashi K, Matsui H, Ando Y.
    Hereditary amyloidosis with cardiomyopathy caused by the novel variant transthyretin A36D.
    Amyloid 23: 207-208, 2016.
  13. Jono H, Su Y, Obayashi K, Tanaka Y, Ishiguro A, Nishimura H, Shinriki S, Ueda M, Ikeda K, Yamagata K, Ichihara K, Ando Y.
    Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism. Scientific Committee for the Asia-Pacific Federation of Clinical Biochemistry.
    Clin Chim Acta 458: 5-11, 2016.
  14. Ando Y, Sekijima Y, Obayashi K, Yamashita T, Ueda M, Misumi Y, Morita H, Machida K, Ohta M, Takata A, Ikeda S.
    Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: a Phase III, open-label study.
    J Neurol Sci 362: 266-271, 2016.
  15. Okumura K, Yamashita T, Masuda T, Misumi Y, Ueda A, Ueda M, Obayashi K, Jono H, Yamashita S, Inomata Y, Ando Y.
    Long-term outcome of patients with familial amyloidotic polyneuropathy V30M after liver transplantation.
    Amyloid 23: 39-45, 2016.
  16. Masuda T, Obayashi K, Ueda M, Fujimoto A, Tasaki M, Misumi Y, Ueda A, Nakane S, Yamashita T, Ando Y.
    Therapeutic effects and prevention of recurrence of acquired idiopathic generalized anhidrosis via intravenous immunoglobulin treatment.
    J Dermatol 43: 336-337, 2016.
  17. Tasaki M, Ueda M, Obayashi K, Motokawa H, Kinoshita Y, Suenaga G, Yanagisawa A, Toyoshima R, Misumi Y, Masuda T, Yamashita T, Ando Y.
    Rapid detection of wild-type and mutated transthyretins: a prospective study.
    Ann Clin Biochem 53; 508-510, 2016.
  18. Misumi Y, Narita Y, Oshima T, Ueda M, Yamashita T, Tasaki M, Obayashi K, Isono K, Inomata Y, Ando Y. Recipient aging accelerates acquired transthyretin amyloidosis after domino liver transplantation.
    Liver Transpl 22: 656-664, 2016.
  19. Yoshimura Y, Kuwabara T, Shiraishi T, Kakizoe Y, Tasaki M, Obayashi K, Ando Y, Mukoyama M.
    Transthyretin-related familial amyloid polyneuropathy found with abnormal urinalysis at a general health checkup.
    Nephrology 21: 341-342, 2016.
  20. Kukidome D, Nishikawa T, Sato M, Igata M, Kawashima J, Shimoda S, Matsui K, Obayashi K, Ando Y, Araki E.
    Measurement of small-fiber pain threshold values for the early detection of diabetic polyneuropathy.
    Diabet Med 33: 62-69, 2016.
  21. Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H.
    Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.
    Int J Oncol 46: 963-972, 2015.
  22. Tanabe H, Higuchi I, Maki Y, Urabe S, Obayashi K, Hokezu Y.
    Myopathy in a patient with systemic AA amyloidosis induced by psoriasis vulgaris: an autopsy case.
    Muscle Nerve 52: 113-117, 2015.
  23. Tasaki M, Ueda M, Matsumoto K, Kawaji T, Misumi Y, Eiki D, Suenaga G, Obayashi K, Yamashita T, Tanihara H, Ando Y.
    Clinico-histopathological and biochemical analyses of corneal amyloidosis in gelatinous drop-like corneal dystrophy.
    Amyloid 22: 67-69, 2015.
  24. Kitagawa K, Misumi Y, Ueda M, Hayashi Y, Tasaki M, Obayashi K, Yamashita T, Jono H, Arima H, Ando Y.
    Inhibition of insulin amyloid fibril formation by cyclodextrins.
    Amyloid 22: 181-186, 2015.
  25. Kon T, Misumi Y, Nishijima H, Honda M, Suzuki C, Baba M, Inomata Y, Obayashi K, Ando Y, Tomiyama M.
    Effects of liver transplantation and tafamidis in familial amyloid polyneuropathy with transthyretin Leu55Pro mutation: A case report.
    Amyloid 22: 203-204, 2015.
  26. Yanagisawa A, Ueda M, Sueyoshi T, Okada T, Fujimoto T, Ogi Y, Kitagawa K, Tasaki M, Misumi Y, Oshima T, Jono H, Obayashi K, Hirakawa K, Uchida H, Westermark P, Ando Y, Mizuta H.
    Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis.
    Mod Pathol 28: 201-207, 2015.
  27. Shinoda K, Taki H, Obayashi K, Ando Y, Watanabe A, Komiya A, Fuse H, Tsuneyama K, Tobe K.
    Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and Sjögren's syndrome.
    Int J Clin Exp Pathol 8: 8624-8627, 2015.
  28. Shinojima N, Nakamura H, Tasaki M, Kameno K, Anai S, Iyama K, Ando Y, Seto H, Kuratsu J.
    A patient with medulloblastoma in its early developmental stage.
    J Neurosurg Pediatr 14; 615-620, 2014.
  29. Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y.
    Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
    J Neurol 261: 2209-2217, 2014.
  30. Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, Kuratsu J, Yamashita S, Ueda M, Li JD, Ando Y, Jono H.
    Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.
    Oncotarget 5: 6353-6364, 2014.
  31. Kajihara R, Sakamoto H, Tanabe K, Takemoto K, Tasaki M, Ando Y, Inui S.
    Protein phosphatase 6 controls BCR-induced apoptosis of WEHI-231 cells by regulating ubiquitination of Bcl-xL.
    J Immunol 192: 5270-5279, 2014.
  32. Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
    Cell Metab 19: 712-721, 2014.
  33. Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, Ando Y.
    Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.
    Stem Cell Res 12: 574-583, 2014.
  34. Nakazono M, Obayashi K, Oshikawa Y, Tani K, Suenaga G, Ando Y, Nanbu S, Kuwano R.
    Unsymmetric indolylmaleimides: synthesis, photophysical property and amyloid detection.
    J Photochem Photobiol A 289: 39-46, 2014.
  35. Nakazono M, Obayashi K, Sasamoto K, Tomiyoshi K, Suenaga G, Ando Y.
    Novel styrylbenzene derivatives for detecting amyloid deposits.
    Clin Chim Acta 436: 27-34, 2014.
  36. Misumi Y, Doki T, Ueda M, Obayashi K, Tasaki M, Tamura A, Ando Y.
    Myopathic phenotype of familial amyloid polyneuropathy with a rare transthyretin variant: ATTR Ala45Asp
    Amyloid 21: 216-217, 2014.
  37. Oshima T, Kawahara S, Ueda M, Kawakami Y, Tanaka R, Okazaki T, Misumi Y, Obayashi K, Yamashita T, Ohya Y, Ihse E, Shinriki S, Tasaki M, Jono H, Asonuma K, Inomata Y, Westermark P, Ando Y.
    Changes in pathological and biochemical findings of systemic tissue sites in familial amyloidotic polyneuropathy more than 10 years after liver transplantation.
    J Neurol Neurosurg Psychiatry 85: 740-746, 2014.
  38. Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H. Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells. Int J Oncol. 2015;46:963-72.
  39. Shinojima N, Nakamura H, Tasaki M, Kameno K, Anai S, Iyama K, Ando Y, Seto H, Kuratsu J. A patient with medulloblastoma in its early developmental stage. J Neurosurg Pediatr. 2014;14:615-20.
  40. Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y. Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration. J Neurol. 2014;261:2209-17.
  41. Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, Kuratsu J, Yamashita S, Ueda M, Li JD, Ando Y, Jono H. Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy. Oncotarget. 2014;5:6353-64.
  42. Kajihara R, Sakamoto H, Tanabe K, Takemoto K, Tasaki M, Ando Y, Inui S. Protein Phosphatase 6 Controls BCR-Induced Apoptosis of WEHI-231 Cells by Regulating Ubiquitination of Bcl-xL. J Immunol. 2014;192:5720-9.
  43. Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K. SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway. Cell Metab. 2014;19:712-21.
  44. Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, Ando Y. Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells. Stem Cell Res. 2014; 12:574-83.
  45. Shinriki S, Jono H, Ueda M, Obayashi K, Nakamura T, Ota K, Ota T, Sueyoshi T, Guo J, Hayashi M, Hiraki A, Nakayama H, Yamashita S, Shinohara M, Ando Y.
    Stromal expression of neutrophil gelatinase-associated lipocalin correlates with poor differentiation in oral squamous cell carcinoma; an opposite finding from its tumoural expression.
    Histopathol 64: 356-364, 2014.

Ⅱ. 邦文原著・著書・総説

  1. 園田優衣大林光念.
    検査レポート作成指南: 検体検査編「NSTレポート」.
    臨床検査 61: 1428-1435, 2017.
  2. 田崎雅義.
    CQ3-6 質量分析 (LC-MS/MS) とはどのような方法か?
    最新アミロイドーシスのすべてー診療ガイドライン2017とQ&A, 医歯薬出版, 2017.
  3. 田崎雅義.
    1.3 免疫の成立と調節.
    臨床免疫検査技術教本, 日本臨床衛生検査技師会, 2017.
  4. 岡﨑敏郎,上山秀嗣,大林光念,安東由喜雄.
    Head up tilt 試験,心筋シンチグラフィー,脳血流シンチグラフィーを用いたパーキンソン病における起立性低血圧の検討.
    自律神経 54: 316-321, 2017.
  5. 増田曜章,大林光念,安東由喜雄.
    皮神経に着目して行う小径線維ニューロパチーの早期診断および病態解析.
    自律神経 54: 230-233, 2017.
  6. 大林光念.
    栄養素の代謝.
    月刊薬事 59: 16-21, 2017.
  7. 大林光念.
    自律神経と循環器疾患の関りはどこまで明らかになったか.
    不整脈 News & Views 43: 8-9, 2017.
  8. 大林光念.
    ニューロパチーの診断と両側性 Horner 症候群.
    自律神経54: 244-247, 2017.
  9. 杉本俊哉, 山下太郎, 田崎雅義, 安東由喜雄, 大林光念, 奥野豊, 畑裕之.
    AL アミロイドーシスにおける質量分析を用いた沈着ペプチド解析.
    臨床血液 58: 589-594, 2017.
  10. 田崎雅義, 大林光念, 安東 由喜雄.
    アミロイドーシスのプロテオーム診断.
    病理と臨床 34: 486-490, 2016.
  11. 大林光念.
    心に残る経腸栄養の患者さんたち2.
    フジメディカル出版, 2016.
  12. 大林光念, 増田曜章, 安東由喜雄.
    Commonな神経疾患における自律神経徴候: IGT ニューロパチー.
    自律神経53: 208-211, 2016.
  13. 大林光念, 柳澤由佳子, 伊崎彩音, 田崎雅義.
    栄養サポートに役立つ血漿蛋白.
    臨床検査 60: 386-392, 2016.
  14. 大林光念, 伊崎彩音, 柳澤由佳子, 田崎雅義, 安東由喜雄.
    知っておきたい専門領域の最近の話題: 神経領域.
    Lab CP34: 7-11, 2016.
  15. 増田曜章, 大林光念, 安東由喜雄.
    新時代の臨床糖尿病学 (下) より良い血糖管理をめざして. 多角的自律神経機能検査 (小径線維障害).
    日本臨床Suppl 2: 240-243, 2016.
  16. 田崎雅義, 大林光念, 安東由喜雄.
    質量分析法を用いたアミロイドーシスの診断・病態解析における新展開.
    臨床病理64: 675-679, 2016.
  17. 大林光念.
    心に残る経腸栄養の患者さんたち:  フジメディカル出版, 2015.
  18. 大林光念
    髄液一般検査, 他4項.
    南山堂医学大辞典, 南山堂, 2015.
  19. 大林光念.
    結膜・網膜血管検査.
    自律神経機能検査第5版, 文光堂, 2015.
  20. 大林光念
    脳循環のautoregulation.
    自律神経機能検査第5版, 文光堂, 2015.
  21. 大林光念, 安東由喜雄.
    多覚的自律神経機能検査法を用いた FAP ATTR Val30Met の早期診断.
    自律神経 52: 119-122, 2015.
  22. 大林光念, 安東由喜雄.
    全身性自律神経ニューロパチーにおける両側性 Horner 症候群
    神経内科 82: 43-46, 2015.
  23. 田崎雅義, 大林光念, 安東由喜雄.
    プロテオミクスを利用した臨床検査: アミロイドーシス診断におけるプロテオーム解析法の有用性.
    臨床病理 63: 980-985, 2015.
  24. 安東由喜雄, 大林光念.
    アミロイドーシスによる自律神経障害.
    自律神経 52: 115-118, 2015.
  25. 池田勝義, 眞部正弘, 上村弘子, 大林光念, 安東由喜雄.
    標準採血法ガイドラインに基づいた採血.
    検査と技術 43: 198-206, 2015.
  26. 山本景一, 大隈雅紀, 池田勝義, 大林光念, 安東由喜雄, 藤本陽子, 手塚美奈, 宮川寿一, 川口辰哉.
    当院NICUにおけるMRSA監視培養の費用対効果最適化への取り組み.
    日本環境感染学会誌 30: 331-335, 2015.
  27. 岡田匡充, 稲富雄一郎, 加藤勇樹, 軸丸美香, 大林光念, 米原敏郎, 安東由喜雄.
    緊張性瞳孔で偶然発見されたRoss症候群の1例.
    臨床神経学 55: 160-164, 2015.
  28. 大林光念, 安東由喜雄.
    多角的自律神経機能検査法をもちいた小径線維ニューロパチーの診断.
    臨床神経 54:1044-1046,2014.
    診療ガイドラインに活用される臨床検査: 神経・筋領域
    臨床検査 58: 61-65, 2014.
  29. 大林光念, 安東由喜雄.
    NSTの機能を高める検査室間連携.
    臨床検査 58: 417-421, 2014.
  30. 田崎雅義大林光念、植田光晴、安東由喜雄.
    パラフィン包埋ホルマリン固定組織切片を利用したLMD-LC-MS/MSシステムによる新たなアミロイドーシス診断法の構築.
    臨床病理 62: 291-296, 2014.
  31. 植田光晴, 大林光念, 池田勝義, 安東由喜雄.
    チーム医療への貢献─NST―
    臨床病理 62: 1137-1142, 2014.

Ⅲ. 卒業研究生進路

2017年度

  • 伊崎彩音 (大学院生): 済生会熊本病院
  • 柳澤由佳子 (大学院生): 九州大学病院
  • 礒口藍斗: 進学 (熊本大学大学院 (医学系) 博士前期課程)
  • 神野渉: 都城市北諸県郡医師会・都城健康サービスセンター
  • 久保田沙耶: 熊本赤十字病院
  • 山本俊介: 熊本中央病院

2016年度

  • 浦川雅貴: 高木病院
  • 金田幸薫: 新古賀病院
  • 園田優衣: 進学 (熊本大学大学院 (保健学系) 博士前期課程)
  • 古賀恵: 済生会熊本病院
  • 中村真琴: 進学 (熊本大学大学院 (医学系) 博士前期課程)

2015年度

  • 比良泰士: 今村病院分院
  • 伊崎彩音: 進学 (熊本大学大学院 (保健学系) 博士前期課程)
  • 柳澤由佳子: 進学 (熊本大学大学院 (保健学系) 博士前期課程)
  • 松本紗也加: 進学 (熊本大学大学院 (医学系) 博士前期課程)
  • 水上真由美: 進学 (熊本大学大学院 (医学系) 博士前期課程)

2014年度

  • 安樂映美: 熊本総合病院
  • 末廣大悟: 北九州総合病院
  • 藤吉えりか: 聖マリア病院
  • 木下祐美子: 進学 (熊本大学大学院 (医学系) 博士前期課程)
  • 竹田真子: 宮崎県立宮崎病院
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